Unveiling two novel and natural weight loss ingredients
Overweight and obesity are chronic and complex diseases caused by excessive accumulation of fat, posing a serious threat to global public health. According to statistics, approximately 43% of adults worldwide are overweight, with 16% being obese. These diseases not only significantly increase the risks of various chronic diseases and premature death, but also often lead to a decline in quality of life and may cause mental health problems such as anxiety, stress, and emotional disorders.
In this context, GLP-1 (glucagon-like peptide-1) receptor agonists, as a new type of drug with both hypoglycemic and weight-loss effects, have received widespread attention and popularity in the global market in recent years. In 2022, the global market size of GLP-1 drugs reached 23.025 billion US dollars, with a year-on-year growth of 43.19%; in the first three quarters of 2023, sales exceeded 25 billion US dollars, demonstrating a strong growth momentum.
Among these drugs, semaglutide stands out as the most popular GLP-1 drug. In 2022, its sales reached 11 billion US dollars, accounting for nearly 50% of the entire GLP-1 market share, fully demonstrating its market dominance and clinical recognition.
Recently, an article published in the Medicina journal stated that the extracts of the plant Dichrostachys glomerata (DGE) and Cissus quadrangularis (CQE) both can promote the secretion of GLP-1 and inhibit the activity of DPP-4, thereby significantly improving body composition and metabolic indicators. These are potential natural components for managing obesity.
The intensity of satiety directly affects the level of calorie intake in the human body. Enhancing satiety helps to reduce weight. Research has found that DGE and CQE can significantly increase satiety, thereby reducing daily energy intake.
In addition, DGE and CQE may also directly influence the browning process of adipose tissue, promote lipid oxidation and enhance anti-inflammatory activity, thereby achieving comprehensive management of obesity through multi-targeted synergy.
The African spice that helps lose weight and reduce stress
Dichrostachys glomerata belongs to the Fabaceae family and the Dichrostachys genus. It has now been revised to Dichrostachys cinerea (the common broom tree). It is a deciduous tree. It is distributed in West Africa (from Senegal to Cameroon), central and eastern Africa (including Sudan, Uganda, etc.), Asia and Australia.
The fruits of the Dichrostachys tree can be eaten. They are usually slender fruit pods, with a texture that is fleshy, hairy, leathery or papery. They contain many seeds, and most of them will split open when mature. The dried and split open fruits can be used as a spice and is a common ingredient in cooking the local traditional soup “Nah po”, often eaten with taro.
Glycyrrhiza glabra is rich in various bioactive components, including flavonoids, phenolic compounds, alkaloids, and tannins, etc. Therefore, in addition to its weight loss effect, it may also bring other health benefits to adults.
As early as over forty years ago, studies reported the blood pressure-lowering effect of Glycyrrhiza glabra. An article published in Food and Chemical Toxicology also indicated that the extract of Glycyrrhiza glabra can be a good source of natural antioxidants, which not only helps to lower the blood sugar and blood pressure of obese patients, but also reduces the risk of cardiovascular diseases in this group of people.
Four-angled Jade Pavilion: A Universal Supplement in the Ayurvedic System
Cissus quadrangularis, commonly known as Four-angled Jade Pavilion or Square Stem Grape, is a tropical perennial plant native to West Africa, Java, Sri Lanka, India, and Malaysia. It has been used as both food and medicine for hundreds of years. In terms of appearance, its stems are light green and nearly quadrangular, the leaves are simple or have lobes, and it produces greenish-white small flowers and fleshy berries.
The Quadrilateral Jade Pavilion contains various pharmacological active components such as terpenes, flavonoids, alkaloids, coumarins, and steroid compounds. Therefore, it has been used as a universal supplement in ancient Ayurvedic medicine. Modern research has further revealed its specific applications in promoting bone health, assisting weight management, and various physiological regulation.
1) Bone Health The Quadrilateral Jade Pavilion has excellent efficacy in treating fractures and is thus called “the Ligament Vine”. Modern scientific research has found that it can regulate bone growth factors (such as IGF-1, NGF), thereby promoting bone remodeling. This makes it not only capable of enhancing bone mass but also effectively accelerating the fracture healing process.
2) Weight Management The Quadrilateral Jade Pavilion shows potential in weight and metabolic management. Its effects include lowering cholesterol, reducing body fat, and improving metabolic syndrome. A 2022 animal study demonstrated that its extract can activate adiponectin receptor 1 (AdipoR1), thereby improving the insulin signaling pathway, and ultimately reducing insulin resistance, hyperlipidemia, and excessive weight gain caused by a high-fat diet.
3) Broad Physiological Regulation Potential Beyond the core uses, the Quadrilateral Vine is also applied in a broader range of health fields due to its diverse biological activities. Literature records indicate that it has analgesic, anti-inflammatory, antioxidant, antibacterial, and wound healing activities. These properties collectively form the basis of its use in traditional medicine to assist in improving various symptoms, such as skin diseases, abdominal pain, epilepsy, anorexia, swelling (inflammation), chronic ulcers, flatulence, dental problems, etc.
Post time: May-20-2026